CO-FACTOR

Enzyme co-factor are non protenious organic or in organic compounds which are essential for efficient function in some enzyme.

Enzyme and co-factor combination is called Holo Enzyme .
The protenious heat unstable enzyme component of holo enzyme is called Apo Enzyme .
Co-factor is non-protenious hence heat stable.

There are 3 types of co-factors
                    1.Enzyme activators 
                    2.Prosthetic groups
                    3.Co-enzymes 

                                        1.Enzyme activators 
                                                                        Enzyme activators are usually inorganic ions,
                                                            
                                          2.Prosthetic group
                                                                       These are non-protenious organic compounds which are firmly integrated to the apo-enzyme.
The bond between apo enzyme and prosthetic group is permanent.
                                                                          ex; FAD, FMN, HAEN,

                                            3.Co-enzyme
                                                            These are non-protenious organic compounds which combines with apo enzyme temporary during the reaction .After the reaction they separate from the enzyme.
                                                                         ex; NAD , NADP